The chapter explores the intersection of neuroscience, neurophysiology, and education, focusing on integrative STEM learning and thinking. The chapter highlights how neuroplasticity, synaptic activity, and neural circuits underpin cognitive processes like memory, attention, and problem-solving. Key concepts such as neuroeducation and integrating neuroscience into teaching practices are discussed to improve STEM education. The chapter identifies the potential of applying neuroscience insights to foster effective pedagogies, reduce neuromyths, and create engaging learning environments. Practical applications include leveraging the brain’s natural learning mechanisms through spaced repetition, retrieval practice, and problem-based learning. Emotional and motivational factors, such as the role of dopamine and the amygdala, are examined for their impact on engagement and learning retention. Key contributions of the chapter are the introduction of two frameworks: The Cognitive and Emotional Neuroeducation: Principles for STEM (CEN-STEM) and the CIRCLE Framework for STEM Neuroeducation. These frameworks offer actionable principles for designing neuroscience-informed STEM education, emphasising inclusivity, cognitive load management, and emotional engagement. The chapter concludes by advocating for interdisciplinary collaboration to align educational strategies with the neural foundations of learning, ensuring evidence-based and impactful teaching practices.