This chapter outlines a systematic approach to collecting and interpreting cardiac data essential for effectively evaluating and managing patients with cardiovascular disease. It emphasizes comprehensive history taking focused on symptoms such as chest pain, dyspnea, palpitations, syncope, and risk factors including hypertension, diabetes, and family history. Physical examination techniques targeting cardiovascular signs, murmurs, jugular venous pressure, and edema are detailed. This chapter guides hospitalists in selecting and interpreting key diagnostic tools and approaching difficult cases. It highlights integrating clinical findings with diagnostic data to formulate differential diagnoses and guide management. The approach prioritizes patient-centered care, risk stratification, and timely collaboration with cardiology and other specialties. This chapter equips hospitalists with practical skills to efficiently assess cardiac patients, enabling accurate diagnosis and optimized treatment plans in the inpatient setting.