Information and Communication Technologies (ICTs) have, in recent years, become increasingly important and fundamental in promoting the inclusion of students with Specific Learning Disorders (SLDs) and Special Educational Needs (SENs) within the classroom, changing the long-established custom of having the pupils follow a specially designed curriculum based on their specific difficulties and differentiated from the rest of the class. The aid of innovative digital teaching methodologies and digital tools such as Serious Games (SGs), proves to be of great effectiveness in increasing the inclusion and integration of pupils with SLD and SEN in the classroom context, both from an educational and relational point of view. This paper proposes a systematic review of the existing scientific literature regarding the development and practical implementation of SGs that assist in the inclusion of students with SLD and SEN, within the whole class learning journey. The research focused on papers dealing with the planning and implementation of SGs designed for Italian schools, as well as papers dealing with the implementation of SGs in Italian educational institutions, of all levels.