The concept of the Triple Helix, based on collaboration among government, industry, and academic institutions, has proven crucial in promoting socio-economic-educational development through innovation. The main idea underlying this work concerns the role of academia as a socio-economic catalyst: indeed, through its traditional research work, it embraces an innovative study approach, defined as the “third mission.” The role of academia has undergone a revolution based on a process that places it at the center not only of knowledge creation but also of knowledge transfer and practical application, implying close interconnection with governmental institutions. This study aims to promote an interdisciplinary and collaborative approach to education by applying the concept of the triple helix to innovative teaching. The goal is to prepare students for a rapidly evolving world, where solutions to problems often require a multidisciplinary approach. This may include practical learning projects, internships in companies, collaborations with government entities, and the development of innovative solutions to local and global challenges. A crucial role in the educational process is played by ICT: by promoting universal access to connectivity and stimulating technological innovation, students are prepared for the challenges offered by the world of digital innovations. Through case studies we will illustrate the ways in which educational institutions can integrate the principles of the Triple Helix into their pedagogical approach.