Human enterprise actions that influence ecosystems are at the front line of humanity’s impacts on the global environment, both in temperate and tropical waters. At the time of writing, micro, small, and medium enterprises (MSMEs) comprised 95% of businesses globally and contributed more than half of total employment, according to the WTO, yet many of them languished because of inadequate value chain and market system support. They were commonly family owned and operated and were predominant in seaweed farming worldwide. Enterprise ecology engages MSMEs in ecoscape communities as they apply arts, sciences, and technologies that influence, manage, and control biosphere ecosystem services valorized through fair ecoeconomic market systems. Seaweed farming enterprises are the true practitioners of adaptive phyconomy, hence phycoecology, and thus enterprise ecology. Profitable enterprises in sustainable ecosystems are essential for the success of initiatives associated with global environmental causes, including UN Sustainable Development Goals, blue ocean, climate change actions, biodiversity, social justice in socioeconomies, eco-economics, and a host of others. Enterprise ecology, as described in this chapter, is a practical framework for building robust enterprises in sustainable ecosystems as necessary for such global environmental solutions to succeed. MSMEs are generally deficient in financing, market systems, and technical support and lack the internal Knowledge, Information, Tools, and Solutions (KITS) required to manage ecosystem services in line with most global environmental initiatives. Failed MSME results in failed initiatives, so means must be found to help them succeed.