Cementless one-stage revision total hip arthroplasty (rTHA) seems to be an effective treatment of early (less than 6 weeks) periprosthetic joint infection (PJI) after primary THA. Cemented modular stems in one-stage septic rTHA with severe femoral bone loss are successful in 81% of cases. The success rate of two-stage rTHA with commercial prefabricated gentamicin-impregnated polymethylmethacrylate (PMMA) articulated hip spacer is 90%. A comparison of two-stage rTHA for PJI with and without a spacer showed that the utilization of antibiotic-loaded cement spacer was superior in terms of reimplantation rate (97% vs. 73%). A comparison of two-stage rTHA for PJI with a spacer versus Girdlestone situation showed the total cure rate was 84% with Girdlestone versus 90%.