The mean incidence of periprosthetic joint infection (PJI) after total ankle arthroplasty (TAA) is around 4%. A two-stage revision TAA (rTAA) is carried out in most of the cases (36%). After a follow-up of 4.2 years, the reported failure rate after irrigation and debridement and polyethylene exchange is 40%, and of rTAA is 9%. The reported reinfection rates for open debridement, antibiotics, and implant retention (DAIR) with or without polyethylene (PE) exchange, one-stage rTAA, two-stage rTAA, cement spacer, and arthrodesis are 39.8%, 0%, 0%, 0.2%, and 13.6%, respectively. Rates of amputation for DAIR with or without PE exchange and cement spacer are 5.6% and 22.2%, respectively. At 3-year follow-up after two-stage rTAA for a chronic PJI (>4 weeks after a primary TAA), 63.6% of patients needed a reoperation.