Knee arthrodesis must be advised as the treatment of choice for individuals who have persistent infected total knee arthroplasty (TKA) after a failed two-stage revision TKA (rTKA). Individuals experiencing knee arthrodesis for TKA periprosthetic joint infection (PJI) had high rates of infection control and preservation of ambulatory status, with low rates of progression to above-the-knee amputation. Intramedullary (IM) nailing accomplishes a substantially higher rate of radiographic union compared with external fixation (EF). The rate of revision arthrodesis procedures is significantly lower for IM nailing compared with EF. IM nailing is more effective than EF with respect to several clinically important results. Knee arthrodesis utilizing a modular IM nail seems to be a good option when rTKA is not an alternative.