Autism Spectrum Disorder (ASD) is a broad neurodevelopmental condition affecting many young learners. Educational efforts are made to meet their needs, overcome deficits and increase their well-being in classroom and everyday activities. The aim of this paper is to review the existing literature regarding the impact of 3D-printing activities and 3D-printed educational models on the learning, engagement, and social integration of children and adolescents with autism. Over 100 relevant articles from Google Scholar and Science Direct are reviewed, with 37 selected for an in-depth analysis. Among them, 13 fully met the study criteria. Best practices in this field are identified in order to analyze challenges and propose solutions for optimizing the application of 3D printing technology in special education. The features and findings of those investigations are illustrated in two tables, including factors such as the type of assistive technology and software, research methodology and target groups, lesson design specifics, observed outcomes, and social needs addressed. Protocols for the design of special education lessons are also reviewed and discussed.