Artificial Intelligence (AI) assumes benefits but also sets out challenges for its regulation, so it is essential to know up to date which international efforts have been made to regulate it, highlighting the importance of promoting the principles of transparency and accountability in the creation and implementation of technologies that use artificial intelligence systems. In addition, the landscape of responsible governance of AI will be displayed to generate trust in users, through the implementation of its principles both nationally and internationally, to maximize the benefits for society and minimize potential risks of its use, through collaboration, among countries and multi-stakeholders for the promotion of trustworthy and ethical AI. The final approach of this document focuses on the presentation of a Latin American proposal based on existing international jurisprudence aimed at the creation of an ex profeso mechanism that contributes to matters related to artificial intelligence in this region, through cooperation and the establishment of strategic alliances with international organizations such as the Organization of American States (OAS), through the Inter-American Juridical Committee, and with the support and participation of other economic blocks at a global scale that have shown their interest in the topic.