The chapter analyzes the use of analytical devices in agriculture and veterinary. Maintaining the health of animals and plants is a serious global problem that requires appropriate scientific approaches and solutions. The analysis conducted in this chapter showed that many agricultural problems can be solved through the use of various sensors. It is shown that along with traditional sensors, paper-based (PB) sensors can be used to monitor soil conditions and the health of plants and animals. They can provide information on soil moisture, temperature, pH, and the presence of nutrients and pollutants in it. PB analytical devices can detect both phytopathogens that affect plant growth and pathogens that affect animal health. PB sensors can also monitor phytohormones, and physiological, immunological, and behavioral responses of animals. Flexible sensors that can be used not only for plant health monitoring but also for tracking animal health are also considered. A comparison of different methods used in agriculture and veterinary is given. The possibilities of PB biosensors for detection of animal diseases and environmental monitoring are discussed. It is concluded that the greatest potential lies in multiplex sensors that can form the basis of PoC devices. These sensors should detect and quantify key molecules related to farm biosecurity, welfare, and overall health of animals and plants, and thus serve as excellent tools for food safety management to improve consumer protection from diseases.