Many organizations and countries are requiring information systems to innovate and break with their legacy systems in many areas in order to be more effective and stand out from their competitors. The education system is one of those areas in need of innovation, as it is one of the fundamental tools for the success of any society. Due to rapid changes and increased complexity, today’s world requires a new educational system that aims to improve the agility and flexibility of students in a highly demanding environment. This study proposes the use of Mixed Reality (MR) in educational systems for teaching STEM subjects to secondary school students, given its proven benefits for both teachers and student performance. Based on a specific case study related to the development of the HoloAnatomy application by CWRU and Cleveland Clinic (USA), as well as the successful learning outcomes of this technology, we present a proposed MR technology to be implemented in the educational system, comprising four subjects and some related content, based on a similar development path.