The several kinds of in vitro instruments and techniques that are employed to preserve the genetic diversity of endangered and uncommon plant species worldwide have been covered in this article. Species that are at risk of going eradicated due to the swift loss of genetic variety and habitat are mostly found in places with limited resources, in underdeveloped regions of the world, in hotspots for biodiversity worldwide, and in island nations. Since only a few tiny populations, or perhaps just a few individuals, of these endemic species are left in the wild, they are special. This compilation of articles explains the direct use of cryopreservation and in vitro techniques, as well as the efforts being made in many places to prevent the extinction of plants. These contributions also offer advice on rare plant propagation, covering methods for large-scale propagation, preservation, and reintroduction.