Endemic plants are species that are native to a specific geographical region and are found nowhere else. These plants are crucial for maintaining biodiversity and ecosystem balance; some of them have special characteristics like Rafflesia arnoldii (Indonesia), which has the largest individual flower, and Cycas beddomei (India), an endangered cycad species endemic to India, important for its prehistoric lineage and medicinal values like rosy periwinkle (Catharanthus roseus), which has a source of alkaloids used in cancer treatment, particularly in drugs like vincristine and vinblastine, which are vital in treating leukemia and Hodgkin’s disease. Neelakurinji (Strobilanthes kunthiana), endemic to India, is traditionally used in Ayurvedic medicine for its supposed anti-inflammatory and rejuvenating properties. Conservation of endemic plants is essential to preserve the unique ecosystems they support and to prevent the loss of irreplaceable plant species. Conventional conservation approaches include in situ methods like protecting natural habitats, creating national parks, and establishing reserves to safeguard plants in their natural environments. Ex situ methods, such as seed banks, botanical gardens, and nurseries, focus on conserving plants outside their natural habitats for research and restoration purposes. In contrast, biotechnical approaches offer innovative solutions for conservation, utilizing tools like tissue culture, cryopreservation, and genetic engineering. These techniques allow for the propagation and preservation of endangered species, helping to overcome challenges like habitat fragmentation and limited population sizes. Combining both conventional and biotechnical methods is key to ensuring the long-term survival of endemic plants, as each approach complements the other by addressing different aspects of conservation challenges.