One of the core structural materials in the world is aluminum, which is inferior in its output and consumption to ferrous metals only. Rolling of metals and alloys conventionally results in their strengthening and, consequently, lowering process ductility. When a definite level of deformation is achieved, process ductility is almost completely lost; and further deformation is impossible without additional heat treatment. The papers [1–3] show that one of efficient methods aimed at improving process ductility is asymmetric rolling. In early 2021, laboratory/industrial asymmetric rolling mill 400 was installed and put into operation at the Zhilyaev Laboratory of Mechanics of Gradient Nanomaterials. It is unique, because a speed ratio of its work rolls may be from 1 to 10. The paper describes a computer simulation and experimental study performed to considerably increase process ductility of aluminum alloys during asymmetric rolling. Therefore, the objective was to study a considerable increase in process ductility of aluminum alloys in broad ranges and develop new process flow charts, contributing to a significant decrease in the number of required additional heat treatment and rolling of aluminum alloys, using laboratory/industrial asymmetric rolling mill 400.