The issues of increasing the efficiency of operation of gas wells in Turkmenistan under watering conditions are considered. Mathematical and computational models are proposed to predict the operation of wells, allowing optimizing the parameters of operation and installation of hydraulic locks. The models take into account the dynamics of changes in gas and water flow rates, pressure and temperature, as well as the physicochemical characteristics of the gas–liquid mixture. The results of field tests at the Naiyp field are presented, confirming the high efficiency of using hydraulic locks. The calculations performed show good agreement with experimental data, which allows increasing the period of trouble-free operation of wells and reducing repair costs.