This work proposes the co-simulation concept applied to the dynamic testing of a new material produced by 3D printing and realized with sandwich structures for being used in the luxury sectors of Made in Italy industries, such as boat interiors, as well as in other key areas of the Italian economy, including cultural heritage restoration and preservation. In particular, this paper explores the material’s behavior, which can be produced as the floor of a boat, in response to the dynamic action of the human walking on the surface for assessing the resistance to trampling. The co-simulation technology involves the interaction between two simulations working in sync, namely Multibody Dynamics (MBD) and Finite Element Method (FEM). It can be considered an emerging tool for adopting multidisciplinary integration. Co-simulation technology is essential for improving the connection between physical and virtual tests, optimizing processes, and efficiently managing data.