This chapter explores the cost-effectiveness of supervised exercise therapy (SET) and revascularization strategies for the treatment of intermittent claudication. A primer on cost-effectiveness analysis is provided, which explains the interpretation of incremental cost-effectiveness ratios in relation to societal willingness-to-pay thresholds. From an economic perspective, SET is the single-most cost-effective treatment strategy for claudication. Specific factors that may influence the cost-effectiveness of revascularization include technological costs, a patient’s overall arterial disease pattern, baseline symptom severity, and the rate of postoperative complications. The chapter underscores the importance of economic evaluations in guiding treatment decisions and promoting cost-effective care in the management of intermittent claudication.