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Bone marrow failure syndromes encompass a diverse and complex group of hematologic disorders that pose significant diagnostic and therapeutic challenges. These conditions, whether acquired or inherited, often result in severe cytopenias, leading to life-threatening complications such as infections, hemorrhage, and progression to myelodysplastic syndromes (MDS) or leukemia. This Textbook of Bone Marrow Failure serves as a comprehensive resource for clinicians, hematologists, transplant physicians, pathologists, researchers, and allied healthcare professionals by providing an in-depth synthesis of knowledge on the epidemiology, pathophysiology, diagnosis, and management of these disorders.

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Introduction

  • 章节

  • 出版模式：

    开放获取

  • 发表日期：

    2026年

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  • Mahmoud Aljurf,
  • Régis Peffault de Latour,
  • Antonio M. Risitano,
  • Andrea Bacigalupo,
  • Carlo Dufour

摘要

Bone marrow failure syndromes encompass a diverse and complex group of hematologic disorders that pose significant diagnostic and therapeutic challenges. These conditions, whether acquired or inherited, often result in severe cytopenias, leading to life-threatening complications such as infections, hemorrhage, and progression to myelodysplastic syndromes (MDS) or leukemia. This Textbook of Bone Marrow Failure serves as a comprehensive resource for clinicians, hematologists, transplant physicians, pathologists, researchers, and allied healthcare professionals by providing an in-depth synthesis of knowledge on the epidemiology, pathophysiology, diagnosis, and management of these disorders.