Lung cancer remains the leading cause of cancer-related morbidity and mortality globally. Early detection through lung cancer screening and management of incidental pulmonary nodules are critical for improving survival rates. This chapter outlines the essential components of developing an effective early lung cancer detection program. Such programs often involve formal lung cancer screening and the ongoing evaluation and follow-up of incidental pulmonary nodules detected in any clinical setting in both people who smoke and those who do not at any age. It emphasizes the importance of multidisciplinary teams, including radiologists, pulmonologists, oncologists, primary care providers, and cancer navigators, in ensuring guideline-directed care and timely follow-up. Chapter 7 also discusses the role and importance of technology and artificial intelligence, such as electronic health records and natural language processing, in identifying eligible patients and managing follow-up care. Quality dashboards serve as tools for continuously monitoring and improving program performance. Additionally, the chapter addresses the economic benefits of early lung cancer detection programs, making a business case for investment in early detection initiatives. By engaging key stakeholders and leveraging available resources, healthcare systems can develop sustainable programs that enhance patient outcomes and reduce lung cancer mortality.