This chapter provides a comprehensive overview of pathological disorders affecting the female genital tract, covering congenital, inflammatory, neoplastic, and functional conditions. It discusses vulvar disorders such as Bartholin’s gland cyst, lichen sclerosus, and vulvar carcinoma. Vaginal pathologies include congenital anomalies, adenosis, and squamous cell carcinoma. Cervical conditions such as cervicitis, endocervical polyps, cervical intraepithelial neoplasia, and carcinoma are explored. Uterine disorders include endometritis, endometriosis, adenomyosis, hyperplasias, and endometrial carcinoma, alongside myometrial tumors such as leiomyoma and leiomyosarcoma. The chapter also examines fallopian tube inflammation and neoplasms, as well as ovarian disorders including cysts, polycystic ovarian syndrome (PCOS), and ovarian tumors. Gestational disorders such as ectopic pregnancy, gestational trophoblastic disease, and placental abnormalities are discussed. Additionally, breast pathology, including inflammatory conditions, fibrocystic changes, benign tumors, and breast carcinoma, is covered. This chapter aims to enhance understanding of these conditions, focusing on pathology, clinical implications, and diagnostic approaches.