This chapter explores the pathology of the male genital system, encompassing disorders of the penis, testis, and prostate. Penile pathologies, including squamous cell carcinoma, are examined with a focus on histological features and clinical implications. Testicular disorders are discussed in detail, including developmental anomalies such as undescended testis and neoplastic conditions such as seminoma, nonseminomatous testicular tumors, and yolk sac tumor. The chapter provides insights into the biology of germ cell neoplasms and the role of Leyding cells in testicular function and tumorigenesis. Prostate pathology is highlighted with discussions on benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and their progression to malignancy. Microscopic findings such as corpora amylacea and their clinical relevance are also covered. The role of processes such as spermatogenesis in male fertility and the pathological disruptions affecting it are outlined. This chapter integrates pathology with clinical and diagnostic perspectives, offering a comprehensive understanding of male genital system disorders.