Harnessing Antibacterial Properties of Chromatic Bacteria to Combat Antibiotic Resistance: Insights from Freshwater and Soil Pigments in Morocco
摘要
Bacterial pigments are classified as secondary metabolites synthesized by bacteria, with roles remain to be fully elucidated, marking an exciting frontier in scientific research. This research aimed to explore bacterial pigments isolated from freshwater and terrestrial ecosystems in Morocco and evaluate their antibacterial potential. 107 freshwater and soil samples were collected from different areas: rivers, lakes, wells, waterfalls, streams, and roadsides of the Middle Atlas and the Tanger-Tetouan-Al Hoceima region. The pigmented bacteria were isolated and identified through optimized cultivation techniques and chemical analyses. The extracts were prepared using different solvents like methanol, dimethyl sulfoxide (DMSO), and ethanol. The pigments were further examined through High-Performance Liquid Chromatography (HPLC), and their antibacterial activity showed inhibitory effects against common pathogens, presenting a sustainable and eco-friendly alternative and offering innovative strategies to address multidrug-resistant bacteria. Bacterial pigments find applications across various industries, including pharmaceuticals, textiles, cosmetics, environmental sustainability, and food preservation. This research not only sheds light on their bioactivity but also positions bacterial pigments as a key resource in the global fight against antibiotic resistance and in the pursuit of sustainable healthcare solutions.