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Type 2 diabetes (T2D) is a chronic metabolic disease and a leading global public health concern, estimated to affect 95 million individuals by 2030 and 136 million by 2045. A literature review was developed and a total of 119 articles were identified. We then filter our data to provide a gene-based analysis of the most well-studied genes in this region. This review included only 65 studies, which carried out 29 from Egypt, 22 from Tunisia, 12 from Morocco, one from Algeria and each one from Mauritania. Data was obtained from PubMed, ScienceDirect and web of science. We aimed to find studies investigating the relationship of genes or polymorphisms with T2D in North African population. A pooled sample of 61,670 was identified, among whom 32,668 were cases (10,036 males and 12,480 females) and 29,002 controls (7749 males and 8866 females). This population was assessed for 60 polymorphisms in 17 unique genes. The present systematic review constitutes a thorough synthesis of current genetic data related to T2D in North African cohorts. The most significant genes identified in this population were TCF7L2 (rs7903146), ACE (I/D variant), MTHFR (C677T and A1298C), KCNJ11 (E23K) and APOE.

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Genetic Susceptibility to Type 2 Diabetes in North African Populations: A Comprehensive Review

  • 会议论文

  • 发表日期：

    2026年

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  • Mohamed Amine Ikhanjal,
  • Chaimae Zouine,
  • Khaoula Errafii,
  • Adnane Benmoussa,
  • Fadil Bakkali,
  • Salsabil Hamdi

摘要

Type 2 diabetes (T2D) is a chronic metabolic disease and a leading global public health concern, estimated to affect 95 million individuals by 2030 and 136 million by 2045. A literature review was developed and a total of 119 articles were identified. We then filter our data to provide a gene-based analysis of the most well-studied genes in this region. This review included only 65 studies, which carried out 29 from Egypt, 22 from Tunisia, 12 from Morocco, one from Algeria and each one from Mauritania. Data was obtained from PubMed, ScienceDirect and web of science. We aimed to find studies investigating the relationship of genes or polymorphisms with T2D in North African population. A pooled sample of 61,670 was identified, among whom 32,668 were cases (10,036 males and 12,480 females) and 29,002 controls (7749 males and 8866 females). This population was assessed for 60 polymorphisms in 17 unique genes. The present systematic review constitutes a thorough synthesis of current genetic data related to T2D in North African cohorts. The most significant genes identified in this population were TCF7L2 (rs7903146), ACE (I/D variant), MTHFR (C677T and A1298C), KCNJ11 (E23K) and APOE.