The main objective of this article is to explore and propose a model for strategic alignment of artificial intelligence (AI) with business processes in the field of personalized e-learning. Indeed, artificial intelligence is increasingly positioning itself as an essential tool for personalized e-learning due to its ability to effectively manage a large number of learners and this according to their profile. However, there are a large number of applications of artificial intelligence in e-learning. These applications of artificial intelligence are sometimes not in line with the business processes that result from the objectives linked to the e-learning system. we note a lack of alignment of artificial intelligence with business processes. This failure obviously hampers the performance of the e-learning system. In order to find a suitable solution in response to this concern, our approach consists, after a literature review, in the implementation of an Ishikawa diagram or cause diagram. This diagram, by pointing out the effect, highlights the different causes. This approach allows, through a systemic approach, to overcome a weakness. The results are based on a model for aligning AI with the personalized e-learning business process.