This chapter explores toxic mentoring in academia and professional settings, focusing on gendered dynamics that worsen these relationships. Mentoring is crucial for career advancement and job satisfaction but can hinder a mentee’s well-being and growth when toxic. It examines gendered challenges, particularly for women in male-dominated fields, in accessing and benefiting from mentorship. The chapter highlights forms of toxic mentoring, including emotional manipulation, favoritism, micromanagement, and harassment, with significant psychological and professional impacts. Case studies illustrate the consequences of toxic mentoring and systemic issues that sustain these behaviors. It calls for culturally sensitive policies and strategies to address toxic mentoring, fostering equitable relationships for all, regardless of gender.