Human adipose-derived stem cells (hADSCs) are a unique type of stem cell with the prospective ability to transform into various cell types. The relatively simple isolation procedure and potential for immediate clinical impact make hADSCs a fascinating stem cell subset. These cells have increasingly been utilized across diverse medical fields, notably in plastic and reconstructive surgery, and have been used to generate adipose, bone, cartilage, neuronal, and other various tissue types. In this chapter, we describe how hADSCs have been utilized in a variety of plastic surgery cases, such as to reconstruct and improve soft tissue defects, aid in bone restoration and remodeling, mitigate degenerative and inflammatory disorders, improve neurological conditions, and promote healing in chronic, radiation, and burn injuries. The medical community should be poised to apply advancements from expanding stem cell research to clinical settings.