3D and 4D Bioprinting Applications in Plastic Surgery
摘要
Three-dimensional (3D) bioprinting is a technique that generates human tissue using a 3D bioprinter. This results in greater precision and matching, besides rendering the surgery safer and faster. In clinical plastic surgery, it is necessary to design specifically shaped biological implants to achieve the desired aesthetic appearance. The advancement of 3D bioprinting is therefore expected to provide a solution to these needs. To simulate the dynamic process of human tissue, four-dimensional (4D) printing, which adds the dimension of time, has been developed. Four-dimensional printing uses smart materials that respond to stimuli over time. Consequently, 4D printing model can exhibit changes in their form, performance, and function in response to appropriate stimuli to meet multiple requirements. This chapter first defines 3D/4D bioprinting technology and describes its basic printing steps, followed by a description of the principles and classification of the printing technology. We provide an overview of the definition and preparation of bioinks and present printing strategies around high precision, gradient printing, and so on. In addition, we detail the use of bioprinting in plastic surgery like rhinoplasty. The chapter concludes with the introduction to the challenges of bioprinting and provides an outlook and summary of the full chapter.