Assistive technology (AT) and artificial intelligence (AI) tools have revolutionized accessibility for individuals with mobility impairments, enabling greater independence and participation in digital environments. This study combines a literature review with insights from two clinical case studies to explore the efficacy of AT and AI solutions in enhancing smartphone and computer accessibility. The literature review, conducted following PRISMA guidelines, identified key advancements in head-tracking software, switch-based systems, and AI-driven accessibility tools. Two case studies were analyzed, both users were assessed at a rehabilitation institute to optimize their accessibility solutions. User A, a quadriplegic adult, after assessment within our rehabilitation institute, utilizes speech recognition AI tool and head-tracking software to control a computer and an app for controlling a smartphone via computer. User B, an adult with spastic quadriplegic cerebral palsy, uses a custom dental appliance with six tongue-operated switches to control a powered wheelchair, a communication device, and a computer. Findings highlight the transformative potential of AT and AI tools in addressing diverse needs, though challenges such as customization and user training remain. This study underscores the importance of personalized solutions and ongoing innovation in AT and AI to improve digital accessibility for mobility-impaired users.