Artificial intelligence (AI) has the potential to transform education for students with Autism Spectrum Disorder (ASD) by providing tailored support that nurtures their potential and well-being. The aim of this study was to explore how ChatGPT can enhance the inclusion and well-being of students with ASD. To this end, a qualitative study was conducted, during which an intervention with ChatGPD was implemented in the Special Unit. Participants included six students, one teacher and three school assistants. Data were collected with participative observation and interview. It was found that there were recurring themes in the students’ inquiries, preference for detailed and structured information, repeated focus on specific topics or areas of interest (e.g. cars), and questions related to social skills, emotional understanding, or coping strategies. ChatGPT served as a safe and non-judgmental medium for students to express emotional concerns or seek help. As a result, targeted interventions were designed and teaching strategies were tailored, so as to incorporate instructions, aids and guidance, based on the students’ queries.