This chapter explores the transformative role of advanced technologies in infection control, focusing on robotics, artificial intelligence (AI), wearable devices, the Internet of Things (IoT), and innovative sterilization methods. Robotics, including UV-C disinfection systems and automated logistics solutions, have enhanced cleaning protocols and minimized healthcare worker exposure to pathogens. AI has revolutionized infection surveillance, leveraging predictive analytics for early intervention, while wearable devices offer real-time health monitoring to detect infections proactively. IoT-enabled smart environments integrate air filtration, automated disinfection, and disease tracking, creating safer healthcare facilities. The chapter also emphasizes sustainability through eco-friendly solutions like electrolyzed water and highlights ethical and economic considerations, including data privacy and accessibility in low-resource settings. While challenges such as cost, training, and infrastructure persist, the compelling benefits of these innovations are shaping the future of infection control, ensuring enhanced patient outcomes and operational effectiveness.