Catheter-associated urinary tract infection (CAUTI) is a common hospital-associated infection, seen in approximately 40% of hospitalised patients. CAUTI is caused by commensal and non-commensal bacteria which enter the bladder via the catheter. E. coli is the most frequent cause of CAUTI. Treatment of UTI is important when it is symptomatic, especially in vulnerable patients, with appropriate antibiotics, based on a urine culture. It is advised to follow up on local regulations. To prevent CAUTI, removal of the catheter is the best way, when it is possible to remove. Assess on a daily basis the need of the catheter and remove as soon as possible. Approximately 69% of CAUTI is preventable, with approximately 9000 preventable deaths. Antibiotic resistance and multi-resistant bacteria are a great danger in treatment options of CAUTI, with 19.2% of all hospital-acquired infections. Placement of the catheter and maintenance must be done in accordance with the (local) guidelines, including adequate hand hygiene. Problems with the catheter should be solved immediately and with the most adequate measures.