Antimicrobial resistance (AMR) is a critical global health threat that requires multifaceted strategies, with antimicrobial stewardship (AMS) playing a central role. Historically, AMS has been physician- and pharmacist-led, overlooking the significant potential of nursing. This chapter highlights the crucial need for and benefits of integrating nurses into AMS programs, addressing misconceptions about their roles, and enhancing their education. Nurses, who comprise the largest healthcare workforce, possess unique patient insights and are crucial for medication administration, patient education, and infection prevention. However, evidence suggests a knowledge gap and a perceived peripheral role in AMS among nurses. To address this gap, educational initiatives, clear role definitions, and institutional support are essential. European and international examples demonstrate successful nurse integration, emphasising the need for collaborative networks and leadership development in the nursing profession. Overcoming professional hierarchies and socioeconomic barriers is vital. Integrating nurses into AMS enhances patient-centred care, optimises antimicrobial use, and strengthens the global fight against AMR, aligning with nursing’s core values of quality and safety.