An essential aspect of realizing an autonomic business model within an enterprise is to develop the necessary strategy and framework to facilitate such a transformation. In this chapter, we explore the foundations of planning and implementing an architecture for autonomic business transformation. We examine how to prepare for the long term by establishing a strategy for AB, developing a business design centered on AI agents, and setting the proper foundation for governing agent operations at scale through establishing an Autonomic Business Operating System (ABOS). The concepts discussed draw upon established best practices from business process management, enterprise architecture, and digital transformation.