The face is the part of the body that other people first notice. Human interaction begins with evaluating body language and facial expressions before verbal communication. Therefore, facial skin conditions are essential for understanding their general body health, age, self-care, and attractiveness. While the appearance of the skin with wrinkles, spots, drooping appearance, and non-homogeneous reflection of light is associated with aging, on the contrary, smooth, taut skin reflects the light homogeneously refers to youth. Throughout history, people have used many methods to renew the skin surface to look younger and more beautiful. Skin peeling, the general name of these methods, is the artificial exfoliation of the outermost layer of the epidermis, sometimes extending deeper, with physical and chemical means. The Assyrians, Egyptians, Babylonians, and Indians used pumice to exfoliate the facial skin physically. Salicylic acid, acetone, resorcinol, solution of formaldehyde, phenol, beta-naphthol, glacial acetic acid, mercurial salts, sulfur, and solid CO2 are chemicals used for skin peeling.