It is possible to reliably feel the facial artery throbbing at the anterior edge of the clenched masseter muscle. The facial artery is typically placed around three centimeters anterior to the angle of the jaw. At the lateral aspect of the nose, where it becomes the angular artery and anastomoses with the infraorbital and dorsal nasal arteries, this is the primary arterial supply of the lower face. It also gives off the inferior and superior labial arteries as it travels toward the lateral part of the nose. Through the anastomoses that are located in this region around the nose, communication can take place between the internal carotid system and the external carotid system. This connection occurs through the angular and ophthalmic artery branches. Avoiding the superior labial artery when performing lip augmentation, effacement of vertical lip rhytides, and augmentation of the nasolabial area. This artery is located deep within the lip mucosa and supplies the septal branch to the nasal area and the columellar branch of the nose simultaneously. When injecting the lower perioral region, it is essential to avoid injecting the mental artery and the labii inferioris branch of the facial artery. These are the two major vessels that should be avoided.