Suicide remains one of the most complex phenomena despite extensive research across various scientific disciplines. The ability to predict and prevent suicide remains minimal, with annual global occurrences reaching alarming numbers. This chapter aims to detail the analysis of suicidality within the context of mood disorders, focusing on depressive disorders and bipolar disorders (BDs), their latent profile, and the potential for clinical management to prevent suicide in these cases. We explore definitions of suicidal behavior (SB), depressive and BDs, and the relationships between these conditions. We wrote our perspective based on the diathesis-stress model, positing that mood disorders, including latent BD, arise from the interaction between genetic, neurobiological, and environmental factors. The primary theories for understanding SBs were considered to elucidate the relationship between suicidality and BD more comprehensively. Evidence of characteristics related to suicidality in mood disorders and conversion to BDs was presented, as well as the clinical implications of these findings to highlight critical factors for better clinical management and future scientific investigations.