Occupational contact dermatitis in healthcare workers is common. Irritant contact dermatitis (ICD) accounts for most occupational dermatitis cases in healthcare workers, while allergic contact dermatitis (ACD) constitutes the rest. ICD in healthcare workers primarily occurs on the hands due to repeated exposure to different chemicals from hand hygiene activities. Alcohol-based hand sanitizers and other antimicrobial agents may directly irritate the skin. Wet work and prolonged occlusion of the skin from gloves are also known to increase the risk of ICD in healthcare workers. The COVID-19 pandemic further contributed to the incidences of ICD in healthcare workers. Factors such as high workload, reduction in manpower, enhanced infection control practices and fear of contracting the disease may have resulted in an increased volume of hand hygiene activities. Chronic ICD will have negative impact and should be managed through primary, secondary, and tertiary preventions. Primary prevention acts to reduce the risk of ICD by elimination and substitution of irritant products with less irritant alternatives, promoting the use of emollients and educating healthcare workers about ICD. Secondary prevention aims to identify and treat early signs and symptoms of ICD, while tertiary prevention consists of medical treatment, work adjustment, and reporting of occupational ICD. A collaborative effort between healthcare workers, employers, and the treating physicians is essential in the management of ICD.