Arsenic (As), known for its toxicity and carcinogenic effects, poses significant environmental and health risks, particularly affecting several millions of people around the world. Through contaminated drinking water. Traditional methods such as oxidation, coagulation, and adsorption have been used for arsenic removal; however, are constrained by cost and maintenance challenges. Consequently, there is a burgeoning interest in using nanotechnology and nanoparticles (NPs) to address these issues in water, soil, and food crops. The sustainable approach of green synthesis in nanotechnology stands out, employing environmentally benign methods to produce NPs for effectively mitigating arsenic contamination in staple food crops. The distinctive qualities of NPs, such as increased surface area and reactivity, enable efficient binding and elimination of arsenic in water and soil, and the goal is to mitigate health hazards linked to arsenic exposure through dietary sources. This chapter offers a detailed analysis of recent advancements and future prospects regarding the implementation of nanoparticles (NPs) for arsenic remediation in food crops. It scrutinises various mitigation strategies, evaluating synthesis techniques, material properties, arsenic removal efficiencies, and mechanisms of action of contemporary nanomaterials. By examining a diverse array of promising nanomaterials, this study aims to propel future research toward efficient, eco-friendly, and cost-effective arsenic removal solutions. Ultimately, it seeks to foster sustainable agricultural practices in food production through innovative nanotechnological approaches.