Arsenic contamination in water sources represents a serious environmental and public health threat. The major health threat associated with exposure to arsenic is the development of different diseases, including cancer, cardiovascular disease, and neurological disease. Environmental deterioration and long-term health problems can arise from repeated contact with arsenic-contaminated soil and water. It makes the creation of efficient treatment plans imperative. An environmentally acceptable and long-lasting option for the removal of arsenic is provided by biological treatment techniques. The use of biofilms and biosorbents, as well as phytoremediation and microbial bioremediation, are some of the biological techniques for treating arsenic that are examined in this article. By using the metabolic powers of bacteria resistant to arsenic, microbial bioremediation transforms hazardous arsenic species into less dangerous ones. Using plants, phytoremediation removes, stabilizes, and changes arsenic from polluted soils and water. Moreover, organic materials and microbial populations produce biofilms and biosorbents that effectively adsorb and accumulate arsenic ions. A viable approach to lowering arsenic levels in polluted settings is the integration of these biological approaches, which have the advantages of being inexpensive, requiring little chemical input, and perhaps having in situ uses. To provide safer water supplies and better environmental health, further study and development is required to maximize these biological therapies, increase their effectiveness, and facilitate large-scale application. This chapter aims to describe the comprehensive approach towards the implementation of biological techniques and explores the application of recent biological advancements towards arsenic treatments.