In recent years, the development of automated systems and the use of artificial intelligence (AI) have transformed the approach to mechanical ventilator weaning, providing tools that allow for a more standardized and even more accurate process. These innovations have promised not only to improve the efficiency of the weaning process, but also to customize it to suit the specific needs of individual patients and even their eventual baseline chronic pathologies. This chapter explores in depth the impact of AI and automated systems on weaning from mechanical ventilation, reviewing the available automated modes and discussing the future perspectives of these technologies applied in intensive ventilatory medicine.