Soil salinity is known as a pervasive environmental stressor, which threats global agricultural productivity. Salinization disrupts soil structure, nutrient dynamics, and plant physiology through osmotic stress, ion toxicity, and oxidative damage, challenging conventional mitigation strategies like chemical amendments or salt-tolerant crop breeding. This work highlights the transformative potential of Plant Growth-Promoting Rhizobacteria (PGPR) as a sustainable, eco-friendly solution to alleviate salinity-induced stress. PGPR enhance plant resilience through multifaceted mechanisms, including ACC deaminase-mediated ethylene reduction, phytohormone synthesis (e.g., auxins, gibberellins), and exopolysaccharide (EPS) production to sequester toxic Na+ ions. They improve nutrient acquisition via nitrogen fixation, phosphate solubilization, and siderophore activity while bolstering antioxidant defenses to counteract reactive oxygen species (ROS). Case studies demonstrate PGPR efficacy across crops such as wheat, rice, soybean, and maize, with strains like Bacillus amyloliquefaciens and Pseudomonas putida enhancing root biomass, photosynthetic efficiency, and yield under saline conditions. Despite promising results, challenges persist in scalability, environmental variability, and socio-economic barriers. Future strategies propose integrating PGPR with biochar amendments, nanoencapsulation for targeted delivery, and CRISPR-Cas9-engineered consortia to optimize stress tolerance traits. Collaborative efforts in precision agriculture, farmer education, and global policy frameworks are critical to translating laboratory breakthroughs into field applications. By harmonizing microbial innovation with ecological stewardship, PGPR-based interventions offer a scalable, sustainable pathway to combat soil salinization, ensuring food security in climate-vulnerable regions. This synthesis underscores PGPR’s role as a cornerstone of next-generation saline agriculture, bridging gaps between research, implementation, and planetary health.