Soil salinity poses a critical threat to global agriculture, reducing crop yields and degrading arable land. This chapter explores the transformative potential of halotolerant plant growth-promoting bacteria (PGPB) in mitigating salt stress and enhancing plant resilience in salt-affected soils. These bacteria, including genera such as Bacillus, Pseudomonas, and Halomonas, employ multifaceted mechanisms to bolster plant survival under salinity. Key strategies include regulating ion homeostasis (via NHX1 and SOS1 genes), modulating phytohormones (e.g., ACC deaminase-mediated ethylene reduction), synthesizing osmolytes (proline and glycine betaine), and enhancing antioxidant defenses to counteract oxidative damage. Halotolerant PGPB also improve nutrient availability by solubilizing phosphorus, fixing nitrogen, and mobilizing potassium, while exopolysaccharides (EPS) mitigate Na+ toxicity and stabilize soil structure. Despite their promise, challenges such as strain specificity, environmental variability, and scalability hinder field applications. Advances in omics technologies and bioengineering offer avenues to optimize microbial consortia and design stress-tolerant strains, while policy frameworks and farmer education are critical for adoption. By integrating microbial solutions with sustainable practices, such as organic amendments and precision agriculture, PGPB can rehabilitate degraded soils, reduce reliance on chemical inputs, and secure food production in saline regions. This synthesis bridges fundamental research with practical strategies, advocating for interdisciplinary collaboration to translate microbial innovations into scalable, equitable agricultural solutions for a salt-affected world.