The study explores the experiences of exposure to environmental risks of women street vendors in Metro Manila, and their local knowledge systems on environmental pollution, health, and climate and disaster risks. It (1) characterizes the composition of street-based populations and their levels of exposure to air and noise pollution, (2) describes the resource-opportunity structure of the streets and their strategies of coping and responding to air and noise pollution, as well as to health and climate and disaster risks, and (3) identifies solution pathways for risk reduction from the perspective of highly exposed and vulnerable populations, including from the urban authorities. Through an ethnographic inquiry, the study used in-depth interviews, life histories, participant observation, direct and indirect observation, informal and unstructured interviews, and focus group discussions. The study reveals that the strategic practices of women street vendors are very much informed by their intimate knowledge of street and community power relations embedded in their perilous environment. This paper hopes to contribute to the literature on bridging, translating, and integrating local knowledge systems on air and noise pollution to environmental justice and climate disasters in cities. The study results provide valuable insights for the larger scientific community, development practitioners, and policymakers on air pollution risks among the most highly exposed and vulnerable street-based population in the cities of the global south.