Strategic land conservation is a global priority to protect species diversity and local native species in the face of climate change, urbanization, and other forms of anthropogenic disturbance. This paper discusses development of a regional spatial decision support system focused on prioritizing climate and water quality resiliency in conservation management. Spatial multi-criteria decision analysis and publicly available datasets were used to weight complementary cross-county resiliency targets. We further explore use of this model in the context of a participatory GIS project for determining microhabitat restoration potential of nonprofit owned lands in an urban county with low overall resiliency. The results show a wide range of biodiversity, connectivity and water quality target values when parcels with faith-based ownership are examined in urbanized areas. The decision analysis and participatory aspects of both projects encourage continued use and manipulation of data to meet community needs in a way that formulaic models, or those covering larger land areas, would not.