The influence of race and ethnicity on the disparities in cancer incidence is a common topic of discussion in clinical research. Studies have found that certain populations are more likely to develop cancer than others. In the UK, researchers have identified cancer incidences while classifying their research populations into local communities mainly as White Europeans, and migrant communities such as Africans, Asians, etc. However, genetic evidence has proved that not all the Whites are indigenous people of the country. Moreover, the other major challenge in the production of cancer incident data reports has shown to be the handling of unknown ethnicity rates when assigning ethnic groups to patients. As a result, these reports are missing essential data and, when produced, are inaccurate and do not truly reflect the reality of the situation on the ground. In this paper, a novel methodology for the classification and list of the ethnic groups in the UK is proposed through classifying the ethnic groups according to the major human Y-Chromosome DNA haplogroups. One of the key benefits of this new proposed methodology is that it provides the actual racial and ethnic classification since each major human Y-Chromosome DNA haplogroup has a site of origin that has natural physical boundaries. Therefore, the proposed ethnic grouping provides the real site of origin which may not always be the country or place of birth, as well as other important data that are highly relevant especially in disease control and prevention to address diseases like cancer and pandemic outbreaks such as coronavirus disease 2019 (COVID-19).