The medicinal prospect of nanotechnology has been widely recognized during the past 10 years as a cutting-edge medication delivery method that supplements conventional pharmacology. Lipid nanocarriers (LNPs) have demonstrated noteworthy pharmacological concert and hopeful therapeutic effects, generating significant attention in research. LNPs include liposomes, ethosomes, Niosomes, nanoemulsions, solid lipid nanoparticles, transferosomes, nanostructured lipid carriers, and polymer hybrid nanoparticles. Their nano-size permits the drug transport to tissues or cells with more precision, longer circulation times, and better cellular absorption. Moreover, these can enable controlled, continuous drug release while lowering their toxicity, which is very advantageous for the treatment of chronic illness. This chapter provides exhaustive information about the various types of LNPs, concentrating on their therapeutic potential in treating multiple diseases. Herein, this chapter also explores the recent research for LNPs to alleviate various diseases, clinical trials, and marketed products.