Breast cancer is one of the leading causes of mortality among women worldwide. Approximately 95% of breast malignancies are adenocarcinomas. Conventional treatments for breast cancer include surgery, radiation, and chemotherapy. Nevertheless, chemotherapy is more effective in treating metastatic breast cancer; however, regardless of the chemotherapeutic class used, the molecules perform a low degree of specificity, resulting in numerous adverse effects. Currently, advances in molecular and technological knowledge have enabled the development and consolidation of immunotherapy, increasing the therapeutic arsenal as a promising treatment alternative directed at different subtypes of breast cancer. Therefore, this chapter proposed to assemble relevant information about the different types of treatments, including immunotherapy based on cytokines, monoclonal antibodies, checkpoint inhibitors, and vaccines in pre-clinical, clinical, and existing on the market as options for breast cancer therapy.