Climate change, which is known as the long-term temperature change and altered weather patterns, has received much attention recently. Its impact on cancer burden and developing cancer in the general population is an important public health issue that is addressed by many researchers. Currently, it is found that climate change can contribute to its adverse consequences, mainly through air pollution, ultraviolet radiation, and increasing temperature. To date, the link between several cancers and climate change has been addressed, including lung, skin, brain, urologic cancers (including bladder, prostate, and kidney), gastrointestinal cancers (encompassing oral, esophageal, gastric, colorectal, and liver cancer), and female cancers (including cervical, ovarian, and breast cancers). In this chapter, current findings on the association between climate change and different cancers have been highlighted and discussed.