The tumor necrosis factor (TNF) and interferon (IFN) are proto- and anti-oncogene that encode for a family of transcription factors which is among the most activated signaling factors in human cancer. In a majority of cancers, the upregulation of TNF and IFN are related to the alternative mechanism pathways. Studies over the past few years have shown that the signaling of inflammatory factors can help tumor cells dysregulation their microenvironment and evade the host immune response system. In this review, we are discussing tumor evasion and its escaping mechanisms for tumor growth and proliferation. We are focusing on the evasion and escape mechanism of both inflammatory factors that have significantly participated in cancer development. We conclude that a deeper understanding of immune evasion and recognition in terms of the role of TNF and IFN could lead to a new therapeutic strategy for the treatment of cancer, and knowledge could be used in relevant clinical experiments involved.